MersV1, Main, Exploration, bibRecord, 001335

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia.

Identifieur interne : 001335 ( Main/Exploration ); précédent : 001334; suivant : 001336

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia.

Source :

Science (New York, N.Y.) [ 1095-9203 ] ; 2016.

RBID : pubmed:26678874

Descripteurs français

English descriptors

KwdEn :
- Animals, Camelus (virology), Coinfection (epidemiology), Coinfection (veterinary), Coinfection (virology), Coronavirus Infections (epidemiology), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Disease Reservoirs (veterinary), Disease Reservoirs (virology), Epidemiological Monitoring, Humans, Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Molecular Sequence Data, Phylogeny, Recombination, Genetic, Saudi Arabia (epidemiology).
MESH :
- classification : Middle East Respiratory Syndrome Coronavirus.
- epidemiology : Coinfection, Coronavirus Infections, Saudi Arabia.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coinfection, Coronavirus Infections, Disease Reservoirs.
- virology : Camelus, Coinfection, Coronavirus Infections, Disease Reservoirs.
- Animals, Epidemiological Monitoring, Humans, Molecular Sequence Data, Phylogeny, Recombination, Genetic.

Abstract

Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our surveillance in Saudi Arabia in 2014 and 2015 showed that viruses of the MERS-CoV species and a human CoV 229E-related lineage co-circulated at high prevalence, with frequent co-infections in the upper respiratory tract of dromedary camels. viruses of the betacoronavirus 1 species, we found that dromedary camels share three CoV species with humans. Several MERS-CoV lineages were present in camels, including a recombinant lineage that has been dominant since December 2014 and that subsequently led to the human outbreaks in 2015. Camels therefore serve as an important reservoir for the maintenance and diversification of the MERS-CoVs and are the source of human infections with this virus.

DOI: 10.1126/science.aac8608
PubMed: 26678874

Affiliations:

Le document en format XML

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<author><name sortKey="Qureshi, Muhammd I" sort="Qureshi, Muhammd I" uniqKey="Qureshi M" first="Muhammd I" last="Qureshi">Muhammd I. Qureshi</name>
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<author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name>
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<author><name sortKey="Alharbi, Njud S" sort="Alharbi, Njud S" uniqKey="Alharbi N" first="Njud S" last="Alharbi">Njud S. Alharbi</name>
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<author><name sortKey="Hajrah, Nahid H" sort="Hajrah, Nahid H" uniqKey="Hajrah N" first="Nahid H" last="Hajrah">Nahid H. Hajrah</name>
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<author><name sortKey="Sabir, Meshaal J" sort="Sabir, Meshaal J" uniqKey="Sabir M" first="Meshaal J" last="Sabir">Meshaal J. Sabir</name>
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<author><name sortKey="Mutwakil, Mohammed H Z" sort="Mutwakil, Mohammed H Z" uniqKey="Mutwakil M" first="Mohammed H Z" last="Mutwakil">Mohammed H Z. Mutwakil</name>
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</affiliation>
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<author><name sortKey="Kabli, Saleh A" sort="Kabli, Saleh A" uniqKey="Kabli S" first="Saleh A" last="Kabli">Saleh A. Kabli</name>
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<author><name sortKey="Alsulaimany, Faten A S" sort="Alsulaimany, Faten A S" uniqKey="Alsulaimany F" first="Faten A S" last="Alsulaimany">Faten A S. Alsulaimany</name>
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<author><name sortKey="Obaid, Abdullah Y" sort="Obaid, Abdullah Y" uniqKey="Obaid A" first="Abdullah Y" last="Obaid">Abdullah Y. Obaid</name>
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<author><name sortKey="Zhou, Boping" sort="Zhou, Boping" uniqKey="Zhou B" first="Boping" last="Zhou">Boping Zhou</name>
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<country xml:lang="fr">République populaire de Chine</country>
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</placeName>
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<author><name sortKey="Smith, David K" sort="Smith, David K" uniqKey="Smith D" first="David K" last="Smith">David K. Smith</name>
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<country xml:lang="fr">République populaire de Chine</country>
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</affiliation>
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<author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name>
<affiliation wicri:level="4"><nlm:affiliation>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
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</placeName>
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<author><name sortKey="Zhu, Huachen" sort="Zhu, Huachen" uniqKey="Zhu H" first="Huachen" last="Zhu">Huachen Zhu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China. Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
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<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Department of Nucleic Acids Research, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, Borg El-Arab, Post Office Box 21934, Alexandria</wicri:regionArea>
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<author><name sortKey="Li, Lifeng" sort="Li, Lifeng" uniqKey="Li L" first="Lifeng" last="Li">Lifeng Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
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<author><name sortKey="Shen, Yongyi" sort="Shen, Yongyi" uniqKey="Shen Y" first="Yongyi" last="Shen">Yongyi Shen</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
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<author><name sortKey="Abo Aba, Salah E M" sort="Abo Aba, Salah E M" uniqKey="Abo Aba S" first="Salah E M" last="Abo-Aba">Salah E M. Abo-Aba</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Microbial Genetics Department, Genetic Engineering and Biotechnology Division, National Research Center, Dokki, Giza, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Microbial Genetics Department, Genetic Engineering and Biotechnology Division, National Research Center, Dokki, Giza</wicri:regionArea>
<wicri:noRegion>Giza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qureshi, Muhammd I" sort="Qureshi, Muhammd I" uniqKey="Qureshi M" first="Muhammd I" last="Qureshi">Muhammd I. Qureshi</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abu Zeid, Mohamed" sort="Abu Zeid, Mohamed" uniqKey="Abu Zeid M" first="Mohamed" last="Abu-Zeid">Mohamed Abu-Zeid</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Microbial Genetics Department, Genetic Engineering and Biotechnology Division, National Research Center, Dokki, Giza, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Microbial Genetics Department, Genetic Engineering and Biotechnology Division, National Research Center, Dokki, Giza</wicri:regionArea>
<wicri:noRegion>Giza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China. Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China. Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khiyami, Mohammad A" sort="Khiyami, Mohammad A" uniqKey="Khiyami M" first="Mohammad A" last="Khiyami">Mohammad A. Khiyami</name>
<affiliation wicri:level="1"><nlm:affiliation>King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Abdulaziz City for Science and Technology, Riyadh 11442</wicri:regionArea>
<wicri:noRegion>Riyadh 11442</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alharbi, Njud S" sort="Alharbi, Njud S" uniqKey="Alharbi N" first="Njud S" last="Alharbi">Njud S. Alharbi</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hajrah, Nahid H" sort="Hajrah, Nahid H" uniqKey="Hajrah N" first="Nahid H" last="Hajrah">Nahid H. Hajrah</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sabir, Meshaal J" sort="Sabir, Meshaal J" uniqKey="Sabir M" first="Meshaal J" last="Sabir">Meshaal J. Sabir</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mutwakil, Mohammed H Z" sort="Mutwakil, Mohammed H Z" uniqKey="Mutwakil M" first="Mohammed H Z" last="Mutwakil">Mohammed H Z. Mutwakil</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kabli, Saleh A" sort="Kabli, Saleh A" uniqKey="Kabli S" first="Saleh A" last="Kabli">Saleh A. Kabli</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alsulaimany, Faten A S" sort="Alsulaimany, Faten A S" uniqKey="Alsulaimany F" first="Faten A S" last="Alsulaimany">Faten A S. Alsulaimany</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obaid, Abdullah Y" sort="Obaid, Abdullah Y" uniqKey="Obaid A" first="Abdullah Y" last="Obaid">Abdullah Y. Obaid</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589</wicri:regionArea>
<wicri:noRegion>Jeddah 21589</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Boping" sort="Zhou, Boping" uniqKey="Zhou B" first="Boping" last="Zhou">Boping Zhou</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, David K" sort="Smith, David K" uniqKey="Smith D" first="David K" last="Smith">David K. Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name>
<affiliation wicri:level="4"><nlm:affiliation>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Huachen" sort="Zhu, Huachen" uniqKey="Zhu H" first="Huachen" last="Zhu">Huachen Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China. Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China. zhuhch@hku.hk yguan@hku.hk.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China. Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China. Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China. zhuhch@hku.hk yguan@hku.hk.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. State Key Laboratory of Emerging Infectious Diseases (The University of Hong Kong-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, China. Shantou University-The University of Hong Kong Joint Institute of Virology, Shantou University, Shantou, China. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Science (New York, N.Y.)</title>
<idno type="eISSN">1095-9203</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Camelus (virology)</term>
<term>Coinfection (epidemiology)</term>
<term>Coinfection (veterinary)</term>
<term>Coinfection (virology)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Reservoirs (veterinary)</term>
<term>Disease Reservoirs (virology)</term>
<term>Epidemiological Monitoring</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (classification)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Recombination, Genetic</term>
<term>Saudi Arabia (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Arabie saoudite (épidémiologie)</term>
<term>Chameaux (virologie)</term>
<term>Co-infection (médecine vétérinaire)</term>
<term>Co-infection (virologie)</term>
<term>Co-infection (épidémiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Phylogénie</term>
<term>Recombinaison génétique</term>
<term>Réservoirs d'agents pathogènes (médecine vétérinaire)</term>
<term>Réservoirs d'agents pathogènes (virologie)</term>
<term>Épidémiosurveillance</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coinfection</term>
<term>Coronavirus Infections</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Co-infection</term>
<term>Infections à coronavirus</term>
<term>Réservoirs d'agents pathogènes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coinfection</term>
<term>Coronavirus Infections</term>
<term>Disease Reservoirs</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term>
<term>Co-infection</term>
<term>Infections à coronavirus</term>
<term>Réservoirs d'agents pathogènes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term>
<term>Coinfection</term>
<term>Coronavirus Infections</term>
<term>Disease Reservoirs</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term>
<term>Co-infection</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Epidemiological Monitoring</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Recombination, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Phylogénie</term>
<term>Recombinaison génétique</term>
<term>Épidémiosurveillance</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our surveillance in Saudi Arabia in 2014 and 2015 showed that viruses of the MERS-CoV species and a human CoV 229E-related lineage co-circulated at high prevalence, with frequent co-infections in the upper respiratory tract of dromedary camels. viruses of the betacoronavirus 1 species, we found that dromedary camels share three CoV species with humans. Several MERS-CoV lineages were present in camels, including a recombinant lineage that has been dominant since December 2014 and that subsequently led to the human outbreaks in 2015. Camels therefore serve as an important reservoir for the maintenance and diversification of the MERS-CoVs and are the source of human infections with this virus. </div>
</front>
</TEI>
<affiliations><list><country><li>Arabie saoudite</li>
<li>Australie</li>
<li>République populaire de Chine</li>
<li>Égypte</li>
</country>
<region><li>Guangdong</li>
<li>Nouvelle-Galles du Sud</li>
</region>
<settlement><li>Shenzhen</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="Arabie saoudite"><noRegion><name sortKey="Sabir, Jamal S M" sort="Sabir, Jamal S M" uniqKey="Sabir J" first="Jamal S M" last="Sabir">Jamal S M. Sabir</name>
</noRegion>
<name sortKey="Alharbi, Njud S" sort="Alharbi, Njud S" uniqKey="Alharbi N" first="Njud S" last="Alharbi">Njud S. Alharbi</name>
<name sortKey="Alsulaimany, Faten A S" sort="Alsulaimany, Faten A S" uniqKey="Alsulaimany F" first="Faten A S" last="Alsulaimany">Faten A S. Alsulaimany</name>
<name sortKey="Hajrah, Nahid H" sort="Hajrah, Nahid H" uniqKey="Hajrah N" first="Nahid H" last="Hajrah">Nahid H. Hajrah</name>
<name sortKey="Kabli, Saleh A" sort="Kabli, Saleh A" uniqKey="Kabli S" first="Saleh A" last="Kabli">Saleh A. Kabli</name>
<name sortKey="Khiyami, Mohammad A" sort="Khiyami, Mohammad A" uniqKey="Khiyami M" first="Mohammad A" last="Khiyami">Mohammad A. Khiyami</name>
<name sortKey="Mutwakil, Mohammed H Z" sort="Mutwakil, Mohammed H Z" uniqKey="Mutwakil M" first="Mohammed H Z" last="Mutwakil">Mohammed H Z. Mutwakil</name>
<name sortKey="Obaid, Abdullah Y" sort="Obaid, Abdullah Y" uniqKey="Obaid A" first="Abdullah Y" last="Obaid">Abdullah Y. Obaid</name>
<name sortKey="Qureshi, Muhammd I" sort="Qureshi, Muhammd I" uniqKey="Qureshi M" first="Muhammd I" last="Qureshi">Muhammd I. Qureshi</name>
<name sortKey="Sabir, Meshaal J" sort="Sabir, Meshaal J" uniqKey="Sabir M" first="Meshaal J" last="Sabir">Meshaal J. Sabir</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Lam, Tommy T Y" sort="Lam, Tommy T Y" uniqKey="Lam T" first="Tommy T-Y" last="Lam">Tommy T-Y Lam</name>
</noRegion>
<name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
<name sortKey="Li, Lifeng" sort="Li, Lifeng" uniqKey="Li L" first="Lifeng" last="Li">Lifeng Li</name>
<name sortKey="Shen, Yongyi" sort="Shen, Yongyi" uniqKey="Shen Y" first="Yongyi" last="Shen">Yongyi Shen</name>
<name sortKey="Smith, David K" sort="Smith, David K" uniqKey="Smith D" first="David K" last="Smith">David K. Smith</name>
<name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name>
<name sortKey="Zhou, Boping" sort="Zhou, Boping" uniqKey="Zhou B" first="Boping" last="Zhou">Boping Zhou</name>
<name sortKey="Zhu, Huachen" sort="Zhu, Huachen" uniqKey="Zhu H" first="Huachen" last="Zhu">Huachen Zhu</name>
</country>
<country name="Égypte"><noRegion><name sortKey="Ahmed, Mohamed M M" sort="Ahmed, Mohamed M M" uniqKey="Ahmed M" first="Mohamed M M" last="Ahmed">Mohamed M M. Ahmed</name>
</noRegion>
<name sortKey="Abo Aba, Salah E M" sort="Abo Aba, Salah E M" uniqKey="Abo Aba S" first="Salah E M" last="Abo-Aba">Salah E M. Abo-Aba</name>
<name sortKey="Abu Zeid, Mohamed" sort="Abu Zeid, Mohamed" uniqKey="Abu Zeid M" first="Mohamed" last="Abu-Zeid">Mohamed Abu-Zeid</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration MERS

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia.

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia.

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	Serveur d'exploration MERS
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